ANTISEPTIC PROPERTIES OF AMINOADAMANTANE DERIVATIVE
Key words: adamantane derivatives, antiseptic properties, fungicidal activity, bactericidal
activity
A B S T R A C T
Development of microbial resistance to current antimicrobial drugs created a critical
need of the new antiseptics. The object of our study was phenyladamantane derivative
(4-(adamantyl-1)-1-(1-aminobutyl)benzol, AM-166). The aim of the presented study was
to investigate the specific activity of 4% AM-166 solution in isopropanol and 5% AM-
166 solution in 76% ethanol (manufactured by PJSC SIC «Borshchahivskiy CPP») against
the wide spectrum of bacteria and fungi, and effective concentrations and exposition time
determination. Desinfectant/antiseptic activity was evaluated by quantitative suspension
method with subsequent neutralization.
Our results showed that both solutions exhibited similar activity against gram-positive
and gram-negative bacteria as well as against yeasts. Antibacterial and antifungal action
was demonstrated for all investigated concentrations (initial solution, 5-fold and 10-fold
dilutions), observed effect was maintained throughout the whole observation period (from
5 to 30 min).
Tested solutions in initial concentrations demonstrated fungicidal activity against
A. niger. 5-fold dilution of 5% AM-166 solution in 76% ethanol was more effective than
5-fold dilution of 4% AM-166 solution in isopropanol. 10-fold dilutions of both solutions
were ineffective against A. niger. The data obtained suggest the prospects of adamantane
derivatives for the development of novel antiseptics.