N. О. VRYNCHANU (https://orcid.org/0000-0003-3450-2108),
T. A. BUKHTIAROVA (https:/orcid.org/0000-0002-2458-8625)
SI «Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine», Kyiv

THE PROBLEM OF RESISTANCE OF MICROORGANISMS – CHALLENGE TO HUMANITY
Key words: resistance of microorganisms, drugs, antibacterial action, microorganisms
A B S T R A C T
One of the XXI century public health urgent problems is the antibiotic therapy effectiveness decrease as a
result of microorganisms resistant strains emergence and spread.
The aim of review is the antibiotic resistance causes and medicines effects on the formation of
microorganisms resistance to antibiotics modern data analysis.
Сontent analysis, bibliosemantic, scientometric and systemic methods was used in the work.
Our analysis showed that at present the question of the non-antimicrobial medicines role in the antibiotic
resistance formation remains open. Medicines of different pharmacotherapeutic groups are able to demonstrate
antimicrobial activity, realizing both by microorganisms inhibition and their growth stimulation. The problem
of such medicines influence on the antibiotics specific activity needs additional investigation in order to possible
antagonistic effects identification. Special attention deserves the question of non-antimicrobial medicines
subinhibitory concentrations accumulation in the environment in view of their ability to stimulate biofilms
formation.
Antibiotic resistance is a global problem; in order to its spread repression and antimicrobial therapy
effectiveness preservation, it is necessary to establish all its possible causes and contributing factors. Non–
antimicrobial medicines role in the resistance formation detection is one of the ways to control these processes.
Such complex measures allow preserving the existing antimicrobial preparations effectiveness for the future
generations.