Hrynchuk N.I.
Institute of Pharmacology and Toxicology of the National Academy of Medical Sciences of Ukraine
ACTIVITY OF N-ALKYL ARYL AMINOPROPANOL DERIVATIVES ON STAPHYLOCOCCUS BIOFILMS
Summary
Nowadays there are no antibacterial medications in clinical practice, effective against biofilms at non-toxic
doses for human. Our studies have shown the significant antibiofilm effect of aminopropanols with N-alkyl
aryl radical. Compound KVM-194 possessed the most pronounced activity against the preformed S. aureus
biofilms at subinhibitory concentration; its action was superior or comparable to referent antimicrobials
ciprofloxacin, azithromycin, gentamicin, rifampicin. The data obtained suggest the promises of novel
aminopropanol derivatives with N-alkyl aryl radical for the development of new antibiofilm drugs.
Keywords: biofilms, microorganisms, S. aureus, aminopropanol derivatives, antibacterial drugs.